I have had few problems setting up various mouse for use in wow - mainly logictek and Razor 5 button setups. Make sure windows is set correctly for your mouse (most of the time "HID- compliant mouse" will work as the hardware setup. Then test it in WOW - wow should recognize the extra buttons. Go into wow keybindings and try pressing button 4 etc on a binding thats not bound - if they work then healbot will recognise them. Just cancel out of the wow keybinding setup screen to scrap the test. Make sure you have the latest drivers and gaming software from logictek. Hope that helps CT